AST of mycobacteria

Antimicrobial susceptibility testing of Mycobacteria

 

Remit of the EUCAST AMST subcommittee

  • Draft an SOP for a reference MIC method
  • Define a set of quality control strains
  • Organise the assembly of a set of reference strains to comprise approximately 100 wild type isolates and 50 identified as resistant to one or two agents (but not MDR MTb).
  • Organise studies to establish reproducibility of the reference method in at least three laboratories.
  • Organise preparation of MIC distributions for the reference strains. The reference MICs will be performed in at least three reference laboratories.
  • Interact with the EUCAST Steering Committee in the setting of breakpoints for antimycobacterial agents.
  • Define the relevance of molecular testing and mutation frequencies.

 

Subcommittee members

Emmanuelle Cambau (chair) France ESGMYC
Thomas Schön  Sweden ESGMYC
Miguel Viveiros Portugal ESGMYC
Miguel Santin Spain ESGMYC
Daniela Cirillo Italy ERLTB-net
Jim Werngren, ESGMYC
Gerard Lina France EUCAST
Johan Mouton Netherlands EUCAST


European Committee on Antimicrobial Susceptibility Testing (EUCAST)

ESCMID study group for mycobacterial infections (ESGMYC)

European Reference Laboratory Network for Tuberculosis (ERLTB-net)