Rationale documents for antifungal agents

Rationale documents for antifungal agents.

Template for producing a Rationale Document (26 June 2014)

• Amphotericin B v 3.0 (26 June 2025)
• Anidulafungin vs. Candida v 5.0 (26 June 2025)

• Caspofungin vs Candida - there is no caspofungin RD and no specific caspofungin breakpoints. Use  anidulafungin and micafungin as markers for caspofungin susceptibility where isolates "S" to  both anidulafungin and micafungin are considered susceptible to caspofungin. Similarly, for C. parapsilosis isolates "I" for anidulafungin and micafungin then can be reported "I" for caspofungin.

• Fluconazole vs. Candida v 3.0 (2020) 
• Flucytosine v 1.0 (22 July 2025)
• Isavuconazole vs. Aspergillus v 3.0 (26 June 2025) 
• Itraconazole v 3.0 (2021)
• Micafungin vs. Candida v 4.0 (26 June 2025)
• Posaconazole v 3.0 (2020) 
• Rezafungin v 2.0 (26 June 2025)
• Voriconazole v 4.0 (2020)  

Archived rationale documents:

• Amphotericin B v 2.0 (4 Februar 2020)
• Amphotericin B vs. Candida v 1.0
• Amphotericin B vs. Aspergillus v 1.0
• Anidulafungin vs. Candida v 4.0 (25 November 2024); Anidulafungin vs. Candida v 3.0 (2020); Anidulafungin vs. Candida  v 2.0 (comments during consultation)
• Fluconazole vs. Candida v 2.0 (comments during consultation) - 2018
• Isavuconazole vs. Aspergillus v 2.0 (4 Februrary 2020); Isavuconazole vs. Aspergillus v 1.0
• Itraconazole vs. Aspergillus v 1.1 (comments during consultation)
• Micafungin vs. Candida v 3.0 (22 November 2024); Micafungin vs. Candida v 2.0 (2020); Micafungin vs. Candida v 2.0 (2020); Micafungin vs. Candida v 1.0 (comments during consultation)
• Posaconazole v 2.0 (this document constitutes a merge and update of previous individual documents: Posaconazole vs. Candida v 1.0 and Posaconazole vs. Aspergillus v 1.0).
• Rezafungin v 1.0 (9 February 2024)
• Voriconazole v 3.0 (19 Dec 2017) (this constitutes a merge and update of previous individual documents: Voriconazole vs. Candida v 2.0 and Voriconazole vs. Aspergillus v 1.0).
• Itraconazole vs. Aspergillus v 2.0 (2020) and Itraconazole vs. Candida v 1.0 - amalgamated 2021 in RD itraconazole v 3.0