Some resistance mechanisms require other than clinical breakpoints for sensitive detection. EUCAST has validated using separate screening cut-offs for the detection of E. coli and K. pneumoniae with ESBL or carbapenemases.
Screening for ESBL and carbapenemases in Escherichia coli, Klebsiella pneumoniae and Salmonella enterica for epidemiological purposes as part of the RAST procedure.
EUCAST Guidelines for detection of resistance mechanisms and specific resistance of clinical and/or epidemiological importance using EUCAST rapid antimicrobial susceptibility testing (RAST) directly from positive blood culture bottles.
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