02.04.2022

How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff values. CMI 2022.

How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff values

Identifying the MIC wild-type distribution and its delineation of species targeted for receiving antimicrobial agent breakpoints is an important first step for determining clinical breakpoints. Having the main responsibility in the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for characterizing the wild-type distributions and setting epidemiological cut-off values (ECOFFs), we explain the why, the how, and frequent misconceptions of wild-type MIC distributions and ECOFFs.

DOI:https://doi.org/10.1016/j.cmi.2022.02.024

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00101-X/fulltext