20.08.2022

EUCAST panels for validating AST methods

EUCAST in collaboration with CCUG (the Culture Collection of the University of Gothenburg, Sweden), and EUCAST NACs, has made panels of organisms with phenotypically well characterized levels of susceptibilityavailable.MIC-values were determined with reference broth micro-dilution and isolates and for several the genome was characterised. Each panel typicaly contains 10 - 20 strains of which some strains have MICs representative of the wild type of the species, and others with typical resistance mechanisms and phenotypically reproducible levels of susceptibility. Each panel highlights a difficult area of susceptibility testing. They will be useful for

• laboratories aiming to validate the accuracy of their AST methods
• validating the quality of commercial material intended for susceptibility testing (the MIC-value or the correct categorisation of S, I and R)
• developers of antimicrobials and AST methods.

• Streptococcus pneumoniae- selection of strains based on varying levels of betalactam susceptibility (2020).
• Pseudomonas aeruginosa- selection of strains with varying susceptibility to many agents, and genetic characterization (2022).