Rationale Documents from EUCAST

The EUCAST Rationale Documents currently available are listed below. Rationale documents for antifungal agents are listed elsewhere, see Antifungal rationale documents".  

The EUCAST rationale documents are explained at

General Information on Rationale Documents

A template for anyone aiming to create a rationale document is available at

Template for producing a Rationale Document (26 June 2014)

Rationale Documents for antibacterial agents:

2019 - 2021: Rationale Documents are currently under review. Many have not been updated with more recent breakpoints. When there are discrepancies between RDs and EUCAST breakpoint Tables or dosing recommendations, always refer to the current version of the breakpoint table. Documents which have been reviewed are dated with the new publication date.

Amikacin v 2.0 (2020-04-30)

Amoxicillin v 1.0

Bedaquiline v 1.0

Benzylpenicillin v 1.0

Cefiderocol v 1.0 (2021-02-08)

Cefotaxime v 1.0

Ceftaroline v 1.0

Ceftazidime v 1.0

Ceftazidime-avibactam v  1.0 (2020-07-30)

Ceftobiprole v 1.0

Ceftolozane-tazobactam v 1.0 (2020-05-15)

Cefuroxime iv v 1.0

Ciprofloxacin v 2.0 (2021-02-08)

Colistin v 1.0

Daptomycin v 1.0

Delafloxacin v 1.0 (2021-02-08)

Delamanid v 1.0

Doripenem v 1.0

Doxycycline v 1.0

Ertapenem v 2.0 (2021-02-08)

Florfenicol (from VetCast) v 1.0

Fosfomycin v 1.0

Fosfomycin-trometamol v 1.0

Fusidic acid v 1.0

Gentamicin v 2.0 (2020-04-30)

Imipenem v 2.0 (2021-02-08)

Imipenem-relebactam v. 1.0 (2021-02-08)

Levofloxacin v 2.0 (2021-02-08)

Linezolid v 1.0

Mecillinam v 1.0

Meropenem v 2.0 (2021-02-08)

Meropenem-vaborbactam v 1.0 (2021-02-08)

Metronidazole  v 1.0

Minocycline v 1.0

Moxifloxacin v 3.0 (2021-02-08)

Mupirocin v 1.0

Netilmicin v 1.1

Nitrofurantoin v 1.0

Nitroxoline v 1.0

Norfloxacin v 1.4

Ofloxacin v 1.4

Phenoxymethylpenicillin v 1.0

Piperacillin-tazobactam v 1.0

Rifampicin v 1.0

Spectinomycin v 1.0

Teicoplanin v 2.1

Tedizolid v 1.0

Temocillin v 1.0 (2020-04-21)

Tetracycline v 1.0

Tigecycline v 1.0  

Tobramycin v 2.0 (2020-04-30)

Trimethoprim v 1.0

Trimethoprim-sulfamethoxazole v 1.0

Vancomycin v 2.1